76 articles - From Friday Oct 27 2023 to Friday Nov 03 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
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| Gastrointest Endosc |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
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Systematic review and meta-analysis: Foods, drinks and diets and their effect on chronic constipation in adults. Fruits and rye bread may improve certain constipation-related outcomes. There is a scarcity of evidence on foods, drinks and diets in constipation and further RCTs are needed. |
| Gut |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Atherosclerotic cardiovascular disease risk profile of patients with chronic hepatitis B treated with tenofovir alafenamide or tenofovir disoproxil fumarate for 96 weeks. Despite on-treatment differences in lipid profiles with TAF and TDF, predicted cardiovascular risk and clinical events were similar for both groups after 96 weeks. |
Open-label, clinical trial extension: Two-year safety and efficacy results of seladelpar in patients with primary biliary cholangitis. Seladelpar was safe, and markedly improved biochemical markers of cholestasis and liver injury in patients with PBC. These effects were maintained or improved throughout the second year. NCT03301506; Clinicaltrialsregister.eu 2017-003910-16. |
| Am J Gastroenterol |
Optimizing the Management Algorithm for Esophageal Dysphagia After Index Endoscopy: Cost-Effectiveness and Cost-Minimization Analysis. Aligning with practice guidelines, routine esophageal motility testing seems cost saving to patients and insurers compared with nonalgorithmic usual care to evaluate nonstructural/mechanical dysphagia. Choice of testing should be guided by index of suspicion. |
| Clin Gastroenterol Hepatol |
BENEFITS OF PROKINETICS, GASTROPARESIS DIET, OR NEUROMODULATORS ALONE OR IN COMBINATION FOR SYMPTOMS OF GASTROPARESIS. Initiating prokinetics as solo new therapy had little benefit for patients with symptoms of gastroparesis. Neuromodulators as the only new therapy decreased symptoms other than nausea and vomiting, especially with non-delayed gastric emptying. Adding gastroparesis diets or neuromodulators to prokinetics offered relief, suggesting that combination therapies may be more useful in managing these patients. (ClinicalTrials.gov NCT02022826). |
Effect of real-time computer-aided polyp detection system (ENDO-AID) on adenoma detection in endoscopists-in-training: a randomized trial. Among endoscopists-in-training, the use of CADe during colonoscopies was associated with increased overall ADR. (ClinicalTrials.gov NCT04838951). |
Health-related Quality of Life in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Multi-center UK Study. Patients with NAFLD, even those without advanced fibrosis, have worse HRQoL compared with the general population. In patients with NAFLD without advanced fibrosis, HRQoL is independently associated with non-liver comorbidities but not LS. Multi-disciplinary management is therefore required in NAFLD, irrespective of fibrosis severity. |
Histological activity in inflammatory bowel disease and risk of serious infections: A nationwide study. Histological inflammation of IBD was an independent risk factor of serious infections, including sepsis, suggesting that achieving histological remission may reduce infections in IBD. |
| Gastroenterology |
An NFATc1/SMAD3/cJUN complex restricted to SMAD4-deficient pancreatic cancer guides rational therapies. Our results suggest that PDAC characterized by SMAD4 deficiency and oncogenic NFATc1/SMAD3/cJUN complex formation exposes sensitivity to a MEKi/gemcitabine combination therapy. |
| Gastrointest Endosc |
A Composite Score of Physiomechanical Esophageal Function Using Functional Lumen Imaging Probe Panometry in Eosinophilic Esophagitis. This composite score of FLIP Panometry metrics, the C2D2 score, may facilitate characterizing physiomechanical function in EoE and serve as an objective outcome measure. |
Impact of Endoscopic Ultrasound in Unresectable Perihilar Cholangiocarcinoma patients in Liver Transplantation work-up. Our current EUS screening for the detection of malignant LN in patients with pCCA eligible for LT shows a limited but clinically important yield. EUS with systematic screening of al LN stations, both regional and non-regional and sampling of 'suspicious' lymph nodes according to defined and set criteria could potentially increase this yield. |
Un-tutored training pathway to achieve competence in esophago-gastric endoscopic submucosal dissection in a Western center. Un-tutored training for esophago-gastric ESD is feasible and allows endoscopists, experienced in therapeutic endoscopy, to achieve the required standards towards competency. |
| Gut |
IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. IL-20 controls colitis and mucosal healing by interfering with the IFN/STAT2 death signalling pathway in IECs. These results indicate new directions for suppressing gut inflammation by modulating IL-20-controlled STAT2 signals. |
Reducing scope 3 carbon emissions in gastrointestinal endoscopy: results of the prospective study of the 'Green Endoscopy Project Würzburg'. Use of fewer instruments per procedure, recycling packaging material and switching to alternative products can reduce carbon emissions without impairing the endoscopic workflow. |
| Hepatology |
Etiology-independent activation of the LTß-LTßR-RELB axis drives aggressiveness and predicts poor prognosis in Hepatocellular carcinoma. This study demonstrates a prognostically relevant, etiology-independent and cross-species consistent activation of a LTß/LTßR/RELB axis in hepatocarcinogenesis. These observations may harbor broad implications for HCC, including possible clinical exploitation. |
Further decompensation in cirrhosis. Results of a large multicenter cohort study supporting Baveno VII statements. In cirrhosis, further decompensation occurs in approximately 60% of patients, significantly increases mortality, and should be considered a more advanced stage of decompensated cirrhosis. |
The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure. We find in two independent cohorts of APAP overdose patients that circulating CXCL14 concentration is a novel early prognostic biomarker for poor outcome which may aid in guiding decisions regarding patient management. Moreover, our findings reveal that CXCL14 performs best when measured soon after patient presentation to the clinic, highlighting its importance for early warning of poor prognosis. |
| J Hepatol |
Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration. The balance of Gata3 and Ramp2 in hepatocytes regulated the proliferation of LSECs and hepatic revascularization via shifting PEDF to VEGFA, which provided potential targets for the prevention and treatment of PHLF. Impact and implications In this study, we revealed a novel mechanism that the balance of Gata3 and Ramp2 in hepatocyte regulated hepatic vascular reconstitution via shifting PEDF to VEGFA during hepatectomy- or ALLPS-induced liver regeneration. We also identified serum PEDF/VEGFA index (SPVI) as a potential predictor for post-hepatectomy liver failure (PHLF) in patients who underwent hepatectomy. This study will provide a better understanding on how hepatocytes contribute to liver regeneration and new targets for the prevention and treatment of PHLF. |
Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model. Chronic circadian dysfunction is an independent carcinogen to human hepatocytes. Mice with humanized livers provide a powerful preclinical model for studying the impact of the necrotic-inflammatory liver environment and neuroendocrine circadian dysfunction in hepatocarcinogenesis and anti-HCC therapy. IMPACT AND IMPLICATIONS-2 Human epidemiological studies have linked chronic circadian dysfunction to increased HCC risk, but direct evidence that circadian dysfunction is a human carcinogen has not been established. Here we show that circadian dysfunction induces nonalcoholic steatohepatitis (NASH)-related carcinogenesis from human hepatocytes in a murine humanized liver model following the same molecular and pathologic pathways observed in human patients. The gene expression signatures of humanized HCC transcriptomes from circadian disrupted mice closely match those of human HCC with the poorest prognostic outcomes, while those from stably circadian entrained mice match those from human HCC with the best prognostic outcomes. Our studies open a new model for defining to the mechanism of NASH-related HCC and highlight the importance of circadian biology in HCC prevention and treatment. |
Hepatocellular carcinoma risk in Sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe. This unique international multicenter cohort of SSA and AS individuals with CHB showed a 5 and 10 year cumulative HCC risk of 1% and 2.4%. The risk of HCC was negligible for individuals without advanced fibrosis at baseline, and among individuals with low baseline (m)PAGE-B scores. These findings can be used to guide HCC surveillance strategies. Impact and implications Sub-Sahara African ethnicity has been associated with a higher risk of hepatocellular carcinoma among individuals with chronic hepatitis B. In this international multicenter cohort study of sub- Saharan African and Afro-Surinamese individuals living with chronic hepatitis B in Europe, we found a 5 and 10 year cumulative incidence of hepatocellular carcinoma of 1% and 2.4%. The risk was negligible among individuals without advanced fibrosis and a low baseline (m)PAGE-B score. These findings can be used to guide HCC surveillance strategies in this population. |
SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease. SIRT5 rs12216101 T>G variant, heightening SIRT5 activity, is associated with liver damage, mitochondrial dysfunction, and oxidative stress in NAFLD patients. Impact and implications In this study we discovered that the SIRT5 rs12216101 T>G variant is associated with higher disease severity in NAFLD patients. This risk variant determines SIRT5 gain-of-function, enhancing mitochondrial oxidative phosphorylation and thus leading to oxidative stress. SIRT5 may represent a novel disease modulator in NAFLD. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Gastroenterology |
| Gut |
Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs. These habitats are challenging to sample, and their low microbial biomass among large amounts of host tissue can make study challenging. Nevertheless, recent findings have shown that many extraintestinal organs that are intimately linked to the gut harbour stable microbiomes, which are colonised from the gut in selective manners and have highlighted not just the influence of the bacteriome but that of the mycobiome and virome on oncogenesis and health. |
| J Hepatol |
Adeno-associated viruses for gene therapy - clinical implications and liver related complications, a guide for hepatologists. The liver community is increasingly being asked to support liver-directed gene therapy to mitigate potential liver associated harm. In this review, we focus on AAV-vector based gene therapy shedding light on this promising technique, its remarkable success in hemophilia gene therapy with a special focus on the hepatic complications and their management in daily clinical practice. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
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| Endoscopy |
| Gastrointest Endosc |
| Gut |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gut |
| J Hepatol |